Kadar D-Dimer Pasien COVID-19 Gejala Sedang Dan Berat Di RSU UKI Periode Juni-September 2021

Tambunan, Jonathan Josafat Ralet (2022) Kadar D-Dimer Pasien COVID-19 Gejala Sedang Dan Berat Di RSU UKI Periode Juni-September 2021. S1 thesis, Universitas Kristen Indonesia.

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Abstract

COVID-19 merupakan penyakit menular pada manusia. Penyakit ini disebabkan oleh virus baru yang mirip dengan SARS-CoV, yaitu SARS-CoV-2. Virus ini menyerang sistem pernapasan manusia, gejala yang ditimbulkan adalah gangguan pernapasan akut seperti batuk, demam diatas 38°C, sesak napas, nyeri otot, malaise, dan diare. Kadar D-Dimer yang meningkat sering ditemukan pada pasien COVID-19 gejala berat. Penelitian yang sudah dilakukan sebelumnya membuktikan bahwa peningkatan kadar D-Dimer dapat meningkatkan risiko kematian dan menjadi penanda prognosis yang kurang baik. Tujuan penelitian ini adalah untuk memberikan gambaran kadar D-Dimer pada pasien terkonfirmasi COVID-19 gejala sedang dan berat di RSU UKI. Desain penelitian adalah potong lintang dengan penyajian data secara deskriptif dan analitik dari dokumen Rekam Medik Rumah Sakit Umum Universitas Kristen Indonesia. Data yang sudah dikumpulkan diolah menggunakan uji Mann-Whitney. Subjek penelitian ini berjumlah 211 pasien yang terkonfirmasi COVID-19 melalui pemeriksaan RT-PCR dan melakukan pemeriksaan kadar D-Dimer. Uji Mann-Whitney yang dilakukan memberikan hasil p-value < 0,05 yang berarti terdapat perbedaan yang bermakna rerata kadar D-Dimer antara pasien COVID-19 gejala sedang dan gejala berat. Rerata kadar D-Dimer pada gejala sedang adalah 441,272 ng/mL dengan jumlah pasien 154 orang. Rerata kadar D-Dimer pada gejala berat sebesar 1.231,630 ng/mL dengan jumlah pasien 57 orang./ COVID-19 is an infectious disease in humans. This disease is caused by a new virus similiar to SARS-CoV, called SARS-CoV-2. This virus attacks the human respiratory system and caused symptoms such as cough, fever above 38°C, shortness of breath, muscle aches, malaise, and diarrhea. Elevated levels of D-Dimer are often found in patients with severe COVID-19 symptoms. Previous studies have shown that increased levels of D-Dimer can increase the risk of death and also a marker of poor prognosis. The purpose of this study was to provide an overview of D-Dimer levels in patients confirmed COVID-19 with moderate and severe symptoms at UKI General Hospital. This study is a cross-sectional study with descriptive and analytic data presentation from the Medical Record document of UKI General Hospital. Data that has been collected was processed using the Mann-Whitney test. The subjects of this study are 211 patients who were confirmed to have COVID-19 through RT-PCR examination and had checked for D-Dimer levels. The Mann-Whitney test that was carried out gave a p-value <0.05, which means that there is a significant difference in the mean D-Dimer level between COVID-19 patients with moderate symptoms and those with severe symptoms. The average level of D-Dimer in moderate symptoms was 441.272 ng/mL with 154 patients. The average level of D-Dimer in severe symptoms is 1,231,630 ng/mL with 57 patients.

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