Korelasi Nilai Cycle Threshold RT-PCR, Luas Lesi Paru Foto Toraks, dan Gejala Klinis dengan Outcome Pasien COVID-19 di RSUD Kota Bandung

Pasalli, Gabriella Hikmah (2022) Korelasi Nilai Cycle Threshold RT-PCR, Luas Lesi Paru Foto Toraks, dan Gejala Klinis dengan Outcome Pasien COVID-19 di RSUD Kota Bandung. S1 thesis, Universitas Kristen Indonesia.

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Abstract

Coronavirus Disease 2019 (COVID-19) merupakan penyakit yang disebabkan oleh SARS-CoV-2 dan telah meluas secara global. Beratnya gejala klinis yang terjadi dapat dikategorikan atas ringan, sedang, berat, dan kritis. Outcome pasien sangat bergantung pada nilai Ct RT-PCR, luas lesi paru pada foto toraks, dan gejala klinis. Desain penelitian ini adalah analitik observasional dengan pendekatan cross sectional. Pengambilan data berasal dari rekam medik pasien COVID-19 yang dirawat di RSUD Kota Bandung pada periode Januari-Juni 2021. Data yang didapatkan di uji dengan uji korelasi Spearman dan uji Regresi Logistik. Dari pasien yang dirawat didapatkan 134 pasien yang memenuhi kriteria penelitian dan sebagian besar adalah laki-laki yaitu 70 orang (52,2%). Sebanyak 71 (53,0%) pasien berusia 46-65 tahun dengan lama perawatan semua pasien ratarata 8-14 hari (61,2%). Gambaran lesi paru patchy sebanyak 94 orang (70,1%) dan melibatkan kedua paru (70,9%). Uji korelasi Spearman didapatkan korelasi yang bermakna antara nilai Ct dengan luas lesi foto toraks (p<0,05). Demikian juga luas lesi paru berdampak pada beratnya gejala klinis (p<0,05). Semakin berat gejala klinis maka outcome semakin buruk (p<0,05). Korelasi antara luas lesi paru dan gejala klinis dengan outcome sangat bermakna (p<0,05) sementara bila nilai Ct RT-PCR diikutsertakan maka korelasinya menjadi tidak bermakna (p>0,05). Korelasi antara nilai Ct RT-PCR, luas lesi foto paru foto toraks, dan gejala klinis dengan outcome pasien COVID-19 yang dirawat di RSUD Kota Bandung tidak bermakna, namun semakin luas lesi pada foto toraks serta gejala klinis pasien semakin berat maka outcome semakin buruk. Kata Kunci: COVID-19, cycle threshold, foto toraks, RALE score, outcome./ Coronavirus Disease 2019 (COVID-19) is a disease caused by SARS-CoV-2 and has spread globally. The severity of clinical symptoms that occur can be categorized into mild, moderate, severe, and critical. Outcome depends on Ct value RT-PCR, lung lesion area of the chest X-ray, and clinical symptoms. The design of this study was observational analytic with a cross sectional approach. Data is taken from the medical records of COVID-19 patients who were treated at the Bandung City General Regional Hospital in January-June 2021. The data obtained were tested with the Spearman correlation test and the Logistics Regression test. From the patients who were treated, there were 134 patients who met the research criteria and most of them were men 70 people (52.2%). 71 (53.0%) patients aged 46-65 years with an average length of treatment for all patients 8-14 days (61.2%). Patchy was the most common pulmonary lesions in 94 people (70.1%) and involved both lungs (70.9%). The Spearman correlation test found a significant correlation between the Ct value and the lung lesion area of the chest x-ray (p<0.05). The lung lesion area of the chest x-ray had an impact on the severity of clinical symptoms (p<0.05). The more severe the clinical symptoms, the worse the outcome (p<0.05). The correlation between the lung lesion area of the chest x-ray and clinical symptoms with outcome were very significant (p<0.05), if the Ct value RT-PCR was included, the correlation was not significant (p>0.05). The correlation between Ct value RT-PCR, lung lesion area of the chest x-ray, and clinical symptoms with the outcome of COVID-19 patients treated at the Bandung City General Regional Hospital was not significant, but the wider the lesion on the chest X-ray and the more severe the clinical symptoms, the more severe the outcome. Keywords: COVID-19, cycle threshold, chest x-ray, RALE score, outcome.

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