Effect of Coffea arabica and Coffea canephora Consumption on Mus musculus Gaster Histopathological Description

Lumaksono, Maria Angela and Kusumo, Pratiwi Dyah and Gultom, Fajar Lamhot (2021) Effect of Coffea arabica and Coffea canephora Consumption on Mus musculus Gaster Histopathological Description. Indonesian Journal of Biotechnology and Biodiversity, 5 (3). pp. 53-60. ISSN 2581 0014

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Abstract

Green coffee bean is the bean from coffee fruit that have not undergone roasting process. The purpose of this research was to determine the gastroprotector effects of arabica green coffee bean (Coffea arabica) and robusta green coffee bean (Coffea canephora) to the histopathology (mucosal layer erosion) of mice’s gastric (Mus musculus). This research used a laboratory experimental design with post-test control group design method. Thirty mices divided into three groups. Mice in the control group were only given standard feed and mineral water. Mice in the treatment group I was given 1,8 ml green bean Coffea arabica solution 5,5%. Mice in the treatment group II was given 1,8 ml green bean Coffea canephora solution 5,5%. Both treatments were carried out for seven days, at the same time. Mice’s gastric made into histopathology slides, and then stained with Hematoxylin Eosin. Overview of the histopathology of the gastric assessed using the Wattimena scoring. The results of the assessment are tested by using the statistical test of Kruskall-Wallis, found the significance value of >0,05, which means there is no effect of green bean Coffea arabica and green bean Coffea canephora against the picture of the histopathological mice’s gastric (Mus musculus), as well as no significant difference between the giving of green bean Coffea arabica and green bean Coffea canephora against the picture of the histopathological mice’s gastric (Mus musculus). Keywords: Green coffee bean, gastroprotective, antioxidants, Wattimena scoring

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