Efikasi dan Keamanan Terapi Hiperimunoglobuin Cytomegalovirus Terhadap Kejadian Infeksi Kongenital Human Cytomegalovirus

Gultom, Abitmer and Sihaloho, Karlos Berlusconi (2025) Efikasi dan Keamanan Terapi Hiperimunoglobuin Cytomegalovirus Terhadap Kejadian Infeksi Kongenital Human Cytomegalovirus. HelFin Journal (Health and Financial Journal), 2 (1). pp. 218-227. ISSN 3026 7374

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Abstract

Latar Belakang: Infeksi cytomegalovirus pada kehamilan dapat menyebabkan cmv kongenital. Terapi hyerimmunoglobulin human Cytomegalovirus (CMV) bertujuan untuk mencegah terjadinya infeksi vertikal kepada janin yang menyebabkan kongenital cmv, Oleh karena itu, penulis melakukan tinjauan literatur sistematis untuk mengetahui khasiat hyperimmunoglobulin dengan meninjau parameter hasil. Metode: Tinjauan literatur sistematis yang mengikuti pedoman Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Hasil: Melalui pencarian data di Pubmed, Science Direct, dan Cochrane menggunakan kata kunci 'Therapy' 'Pregnancy' 'Pregnant' 'Cytomegalovirus' ‘Treatment’, didapatkan 230 artikel. Kemudian dilakukan seleksi, terdapat 52 artikel yang tereklusi, Review artikel sebanayak 43, case control studies sebanyak 30, cohort studies sebanyak 35, dan observational studies sebanyak 71 artikel, sehingga didapatkan 2 jurnal yang memnuhi kriteria iklusi. Kesimpulan sebanyak 30% dan 35,6% kejadian kongenital CMV pada kelompok ibu yang diberikan HIG, dibandingkan dengan kelompok kontrol yaitu sebesar 44%. Kata kunci: Hiperimmunoglobulin, Cytomegalovirus, Kehamilan, Terapi. / Background: Cytomegalovirus infection in pregnancy can cause congenital human Cytomegalovirus (CMV). CMV hyperimmunoglobulin therapy aims to prevent vertical infection to the fetus causing congenital CMV, therefore, the authors conducted a systematic literature review to determine the efficacy of hyperimmunoglobulin by reviewing outcome parameters. Methods: Systematic literature review following the Preferred Reporting Items for Systematic Reviews and Meta- Analysis (PRISMA) guidelines. Results: Through data search in Pubmed, Science Direct, and Cochrane using the keywords 'Therapy' 'Pregnancy' 'Pregnant' 'Cytomegalovirus' 'Treatment', 230 articles were obtained. Then the selection was carried out, there were 52 articles that were excluded, 43 review articles, 30 case control studies, 35 cohort studies, and 71 observational studies, so that 2 journals were obtained that met the inclusion criteria. Conclusion: as much as 30% and 35.6% of CMV congenital events in the group of mothers given HIG, compared to the control group which was 44%. Keywords: Hyperimmunoglobulin, Cytomegalovirus, Pregnancy, Treatment

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