ROLE OF SDF-1 AND CELECOXIB IN INCREASING QUANTITY OF NEURAL STEM CELL IN THE LESION ZONE AND OUTCOME OF SPONTANEOUS INTRACEREBRAL HEMORRHAGE

Sinurat, Robert and Maskoen, Ani Melani and Hilmanto, Dani and Wiriadisastra, Kahdar (2016) ROLE OF SDF-1 AND CELECOXIB IN INCREASING QUANTITY OF NEURAL STEM CELL IN THE LESION ZONE AND OUTCOME OF SPONTANEOUS INTRACEREBRAL HEMORRHAGE. International Journal of Pharmacy and Pharmaceutical Sciences, 8 (7). pp. 399-403. ISSN 0975 1491

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Abstract

Objective: We studied the effect of stromal derived factor-1 (SDF-1) and celecoxib for increasing the amount of neural stem cells in the lesion zone and clinical outcomes of spontaneous intracerebral hemorrhage. Methods: Twenty-eight rats, strain Wistar, divided into four groups: control, treated with celecoxib, SDF-1, and the combination of celecoxib+SDF-1. The neural stem cells identified by immunohistochemistry procedures with Nestin as primary antibodies and the levels of proliferation were assessed by Ki-67 as primary antibodies. The clinical outcomes were examined by Bederson scale. Results: This study revealed the combination treatment group had the highest histoscores of Nestin and highest of Ki-67 histoscores for SDF-1 group. The amount of neural stem cells in the lesion zone of treatments groups was higher than controls (p<0.005), but similar between treated groups (P>0.05). The proliferation levels were higher in SDF-1 group (P<0.05), and the clinical outcomes back to normal were highest in combination therapeutic groups, even though not different when compared to another group (p>0.05). Conclusion: The results suggest celecoxib, SDF-1, and the combination of celecoxib+SDF-1 can increase neural stem cells in spontaneous intracerebral hemorrhage, and SDF-1 increased proliferation levels. The clinical outcomes were not significantly different between rats, regardless of the fact that almost all of rats in the combination group were back to normal.

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