Perbaikan Kualitas Hidup Penderita Refluks Laringofaring Setelah Mendapat Terapi Proton Pump Inhibitor (PPI) di Bagian Poliklinik THT-KL RSU UKI Periode Januari 2021 – Februari 2021

Zebua, Ribka Liliana (2021) Perbaikan Kualitas Hidup Penderita Refluks Laringofaring Setelah Mendapat Terapi Proton Pump Inhibitor (PPI) di Bagian Poliklinik THT-KL RSU UKI Periode Januari 2021 – Februari 2021. S1 thesis, Universitas Kristen Indonesia.

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Abstract

Latar belakang: Refluks laringofaring ialah keadaan dimana terjadi refluks isi lambung ke esofagus hingga mencapai laring dan faring sehingga membran mukosa laring, faring, dan organ respiratori lainnya mengalami inflamasi. Gejala-gejala refluks laringofaring dapat mengganggu aktivitas sehari-hari, sehingga dapat menimbulkan penurunan kualitas hidup penderitanya. Proton Pump Inhibitor (PPI) merupakan terapi utama untuk penderita refluks laringofaring. Pemberian PPI dapat memperbaiki gejala-gejala yang dialami oleh penderita refluks laringofaring. Tujuan: Mengetahui kualitas hidup penderita refluks laringofaring setelah mendapat terapi PPI. Metode: Penelitian kuasi eksperimental dengan menggunakan pre and post test design dari Januari 2021 hingga Februari 2021, pada 18 subjek penelitian yang dinilai kualitas hidupnya dengan menggunakan RSI. Setiap subjek diberikan lansoprazole 30 mg dua kali sehari sebelum makan selama 14 hari. Pengamatan dilakukan dua kali, yaitu sebelum terapi dan 14 hari setelah pemberian terapi. Analisis data dengan menggunakan paired sample T-test. Hasil: Terdapat perbaikan kualitas hidup yang signifikan pada penderita refluks laringofaring berdasarkan skor RSI setelah 14 hari pemberian lansoprazole 30 mg (p<0,05). Kesimpulan: Pemberian terapi PPI dapat memberikan perbaikan kualitas hidup yang signifikan pada penderita refluks laringofaring. Kata Kunci: Kualitas hidup, refluks laringofaring, Reflux Symptom Index (RSI), Proton Pump Inhibitor (PPI). / Background: Laryngopharyngeal reflux (LPR) is a condition in which gastric content reflux to the oesophagus and reaches larynx and pharynx so that mucous membranes of the larynx, pharynx, and other respiratory organs are inflamed. The symptoms of LPR can affect daily activities, resulting in a decrease in the quality of life (QOL) of the patients. Proton Pump Inhibitor (PPI) is the main therapy for patients with LPR. PPI can improve the symptoms experienced by patients with LPR. Objective: Determine the QOL of patients with LPR after receiving PPI. Methods: Quasi-experimental studies using pre and post-test design from January 2021 to February 2021, in 18 patients were assessed for QOL scores using RSI. Each patient was administered lansoprazole 30 mg twice daily before meals for 14 days. Two times of observations are done, before therapy and 14 days after therapy. Data analysis using paired sample T-test. Results: There were significant improvement in QOL of patients with LPR on RSI scores after 14 days of administration of lansoprazole 30 mg. (p<0,05). Conclusions: PPI significantly improved the QOL of patients with LPR. Keywords: Quality of life (QOL), Laryngopharyngeal Reflux (LPR), Reflux Symptom Index, Proton Pump Inhibitor (PPI).

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