Resistensi Plasmodium Falciparum

Isnaini, Yunita (2015) Resistensi Plasmodium Falciparum. S1 thesis, Universitas Kristen Indonesia.

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Abstract

Resistensi Plasmodium terhadap obat antimalaria adalah kemampuan parasit untuk tetap hidup dan berkembang biak meskipun diobati dengan obat antimalaria dengan dosis yang biasa digunakan atau dengan dosis yang lebih tinggi yang masih dapat ditoleransi oleh penderita. Resistensi terhadap obat antimalaria terjadi akibat mutasi spontan pada parasit malaria. Mutasi bisa terjadi pada satu titik mutasi, tetapi juga bisa terjadi mutasi multipel. Terjadinya mutasi dipengaruhi oleh berbagai faktor yang berhubungan dengan obat, parasit dan manusia sebagai hospes Plasmodium. / Plasmodium resistance to antimalarial drugs is the ability of the parasite to survive and multiply despite treatment with antimalarial drugs at doses normally used or at a higher dose that can be tolerated by the patient. Antimalarial drug resistance is caused by spontaneous mutations in the malaria parasite. Mutations can occur at a single point mutation, but also can occur multiple mutations. Mutations are influenced by various factors related to the drug, the parasite Plasmodium and humans as hosts.

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