IMMUNOLOGY BEHIND THE GRANULOMA ec FILLER

Harlim, Ago (2017) IMMUNOLOGY BEHIND THE GRANULOMA ec FILLER. In: 26th EADV Congress, 13-17 September 2017, Geneva.

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Abstract

Silicone injection for cosmetics and surgery is still widely practiced in Indonesia. The result of Indonesian Association of Plastic Surgeons survey start from 2004 to 2007, found 249 cases of silicone complications.1 Epidemiological data in other countries was not clear because silicone injection had been banned. In 1990, more than 100,000 patients in United States had received silicone injection in their face.3 In Indonesia, there had been no research on silicone injection and its complications, although the cases were abundant. The use of silicone injection for cosmetic treatment had been banned by Federal Food, Drug & Cosmetic America (FDA) since 1992.3 Liquid silicone which was injected into the skin can migrate and cause morphological changes and uncontrolled inflammatory response. Liquid silicone in the tissue is persistent, so it will lead to chronic inflammation and granulomas formation, if severe, it could be followed by infection, necrosis, and abscess.2-4 Silicone granuloma is difficult to evacuate and is still able to form new granuloma after the evacuation. Immune response of granuloma is mediated by T cells, Th1 secreted pro inflammatory cytokines and Th2 secreted anti inflammatory cytokines.18

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