Aktivitas Antibakteri Ekstrak Kulit Manggis (Garcinia mangostana L.) terhadap Methicillin-resistant Staphylococcus aureus ATCC 33591

Thomas, Shindy Christin (2023) Aktivitas Antibakteri Ekstrak Kulit Manggis (Garcinia mangostana L.) terhadap Methicillin-resistant Staphylococcus aureus ATCC 33591. S1 thesis, Universitas Kristen Indonesia.

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Abstract

Infeksi termasuk dalam permasalahan kesehatan yang terus meningkat di negara tropis termasuk Indonesia. WHO merekomendasikan untuk pengobatan alternatif dengan memanfaatkan bahan alam. Ekstrak kulit manggis diketahui memiliki beberapa kandungan senyawa dengan efek farmakologi salah satunya adalah antimikroba. Penelitian ini dilakukan untuk mengetahui aktivitas antibakteri dari ekstrak kulit manggis (Garcinia mangostana L.) terhadap pertumbuhan bakteri MRSA. Penelitian ini termasuk dalam jenis eksperimental secara in vitro dengan metode Kirby-Bauer. Menurut tabel Greenwood, hasil uji antibakteri ekstrak kulit manggis dengan berbagai konsentrasi diperoleh rata-rata zona hambat pada konsentrasi 100 mg/ml hingga 25 mg/ml termasuk kategori lemah, kategori 6,25 mg/ml sampai 1,56 mg/ml termasuk kategori yang tidak terdapat aktivitas antibakteri, sedangkan pada kontrol positif termasuk kategori sedang. Menurut hasil penelitian, ekstrak metanol kulit manggis (Garcinia mangostana L.) memiliki kemampuan untuk menghambat pertumbuhan bakteri Methicillin-resistant Staphylococcus aureus (MRSA) sehingga berpotensi sebagai antibakteri. Kata kunci: antibakteri, Garcinia mangostana L., Methicillin-resistant Staphylococcus aureus (MRSA). / Infection is increasing health problems in tropical countries including Indonesia. WHO recommends for alternative medicine by utilizing natural ingredients. Mangosteen peel extract consists of compounds that have pharmacological effects, one of which is antimicrobial. The purpose of this research was to determine the antibacterial activity of mangosteen peel extract (Garcinia mangostana L.) against the growth of MRSA bacteria. This research is included in the in vitro experimental type with the Kirby-Bauer method. According to the Greenwood table, antibacterial test results of mangosteen peel extract with various concentrations were obtained on average inhibition zones at concentrations of 100 mg/ml to 25 mg/ml including the weak category, category 6.25 mg/ml to 1.56 mg/ml including categories with no antibacterial activity, while positive controls included the medium category. According to the research results, methanol extract of mangosteen peel (Garcinia mangostana L.) can inhibit the growth of Methicillin-resistant Staphylococcus aureus (MRSA) bacteria so that it has the potential as an antibacterial. Keywords: antibacterial, Garcinia mangostana L., Methicillin-resistant Staphylococcus aureus (MRSA)

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