Hubungan Terapi Farmakologi dengan Kadar HbA1c Akhir pada Pasien DM Tipe 2 di RS Mitra Medika Pontianak

Kusumo, Christian Adi (2023) Hubungan Terapi Farmakologi dengan Kadar HbA1c Akhir pada Pasien DM Tipe 2 di RS Mitra Medika Pontianak. S1 thesis, Universitas Kristen Indonesia.

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Abstract

Diabetes Melitus tipe 2 (DM tipe 2) adalah jenis diabetes yang paling umum di seluruh dunia dan diartikan sebagai gangguan metabolik kronik yang ditandai dengan kondisi hiperglikemia atau peningkatan kadar gula darah diatas batas normal. Indonesia sendiri menduduki peringkat ke-3 dari seluruh negara di Asia Tenggara. Kejadian DM tipe 2 di Indonesia didapatkan sebanyak 11,3% dengan presentase 3,9% pada kelompok usia 45 – 54 tahun, diikuti dengan 6,0% pada kelompok usia 65 – 74 tahun dan tertinggi pada kelompok usia 55 – 64 tahun dengan presentase 6,3%. Penelitian ini dilakukan untuk melihat gambaran kadar, HbA1c, GDP, LDL dan kombinasi terapi farmakologi pada penderita DM tipe 2 dan penelitian ini melihat korelasi antara terapi farmakologi (terapi antidiabetes oral tunggal dan terapi kombinasi antidiabetes oral dengan insulin) dengan kadar HbA1c akhir pemeriksaan pada subjek DM tipe 2. Jenis penelitian ini merupakan studi analitik cross-sectional dengan uji statistik chi square menggunakan data dari observasi rekam medis Rumah Sakit Mitra Medika Pontianak Periode Juni 2019 – April 2021. Terdapat 43 sampel yang diambil berdasarkan teknik pengambilan sampel purposive sampling. Hasil analisis univariat menunjukkan sampel terbanyak pada kelompok usia 40 – 59 tahun (58%), perempuan (55,8%), kadar HbA1c ≥7% (65,1%), kadar GDP >126 mg/dL (70%), kadar LDL <130 mg/dL (72%) dan paling banyak menerima 2 OAD oral (34,9%). Hasil analisis bivariat memperlihatkan terapi farmakologi tidak berhubungan dengan kadar HbA1c (nilai p 1,000). Kata Kunci: Diabetes Melitus tipe 2, HbA1c, GDP, LDL, OAD Oral, Insulin. / Diabetes Mellitus type 2 (DM type 2) is the most common type of diabetes worldwide and it’s defined as a chronic metabolic disease characterized by hyperglycemia or increased blood sugar levels above normal limits. Indonesia itself is ranked 3rd out of all countries in Southeast Asia. The incidence of type 2 DM in Indonesia was obtained as much as 11.3% with a percentage of 3.9% for the age range of 45-54 years is 3.9%, while the age range of 65-74 years has a higher percentage of 6.0%. The highest percentage is found in the age group of 55-64 years, which is 6.3%. The purpose of this research was to identify the characteristics of HbA1c levels, Fasting Blood Glucose (FBG) levels, LDL levels and combination of pharmacological therapy among individuals diagnosed with type 2 DM. This study also looked at the relationship of pharmacological therapy (oral antidiabetics and combination of oral antidiabetics with insulin) to HbA1c levels in patients with type 2 DM. This type of research is a cross-sectional analytic study with chi square statistical test using data from observation of medical records at Mitra Medika Pontianak Hospital for the period June 2019 – April 2021. The sampling technique is purposive sampling, and the number of samples is 43 samples. The results of univariate analysis showed the most samples in the age group of 40-59 years (58%), women (55.8%), HbA1c levels ≥7% (65.1%), FBG levels >126 mg / dL (70%), LDL levels <130 mg / dL (72%) and mostly given 2 Oral Antidiabetics (34,9%). According to the bivariate analysis findings, there was no correlation between pharmacological therapy and HbA1c levels, as indicated by p-value of 1,000. Keywords: Type 2 DM, HbA1c, FBG, LDL, Antidiabetics, insulin

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