Hubungan Kadar Ureum Terhadap Kadar Hemoglobin Selama Tiga Bulan Pada Pasien Penyakit Ginjal Kronik Stadium V Di Rumah Sakit Umum Universitas Kristen Indonesia Periode 2015 – 2017

Andrianto, Dopang (2019) Hubungan Kadar Ureum Terhadap Kadar Hemoglobin Selama Tiga Bulan Pada Pasien Penyakit Ginjal Kronik Stadium V Di Rumah Sakit Umum Universitas Kristen Indonesia Periode 2015 – 2017. S1 thesis, Universitas Kristen Indonesia.

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Abstract

Penyakit ginjal kronik (PGK) stadium V merupakan keadaan kerusakan ginjal yang ditandai dengan penurunan laju filtrasi glomerulus < 15 mL/menit/1,73 m2 yang telah terjadi lebih dari tiga bulan. Pasien PGK stadium V harus melakukan hemodialisis dan salah satu komplikasi yang paling sering diderita akibat tatalaksana tersebut adalah anemia. Anemia ini disebabkan akibat prosedur hemodialisis dan toksik uremik. Kadar ureum yang tinggi dalam plasma dapat menghambat proses eritropoesis di sumsum tulang dan menginduksi terjadinya fagositosis pada eritrosit. Penelitian ini bertujuan untuk mengetahui hubungan antara kadar ureum terhadap kadar hemoglobin sebelum dan sesudah tiga bulan melakukan hemodialisis. Penelitian ini menggunakan metode analitik retrospektif dengan pendekatan cross sectional. Sampel yang digunakan sebesar 55 pasien sesuai kriteria inklusi. Data diambil dari hasil laboratorium yang tercatat di rekam medis pasien PGK stadium V di RSU UKI periode 2015-2017. Uji statistik menggunakan uji Paired t-test didapatkan kadar ureum pre-post hemodialisis tidak terdapat perbedaan signifikan (p = 0,143; p > 0,05) sedangkan kadar hemoglobin pre-post hemodialisis terdapat perbedaan signifikan (p = 0,032; p < 0,05). Uji statistik menggunakan uji korelasi Pearson didapatkan hubungan signifikan pada pre hemodialisis (p = 0,00; p < 0,05; r = -0,460) dan post hemodialisis (p = 0,03; p < 0,05; r = -0,391). Kesimpulan penelitian ini bahwa terdapat hubungan yang signifikan antara kadar ureum terhadap kadar hemoglobin selama tiga bulan melakukan hemodialisis. Kata Kunci : Anemia, Hemoglobin, Penyakit Ginjal Kronik, Ureum Chronic kidney disease (CKD) stage V is a condition of kidney damage characterized by a decrease in glomerular filtration rate <15 mL/minute/1.73 m2 which has occurred more than three months. Patients with CKD stage V must do hemodialysis and one of the most common complications resulting from this treatment is anemia. This anemia is caused by a hemodialysis procedure and uremic toxin. High levels of urea in the plasma can inhibit the process of erythropoesis in the bone marrow and induce phagocytosis in erythrocytes. The purpose of this research is for know the relationship between urea level and hemoglobin level before and after three months of hemodialysis. This research uses a retrospective analytic method with cross sectional approach. The sample used was 55 patients according to the inclusion criteria. Data was taken from laboratory results recorded in the medical record of patients with CKD stage V at RSU UKI period 2015-2017. Statistical tests using Paired t-test showed that there was no significant difference between pre-post hemodialysis urea level (p = 0,143; p > 0,05) whereas significant difference between pre-post hemodialysis hemoglobin level (p = 0,032; p < 0,05). Statistical tests using Pearson correlation test found a significant relationship to pre hemodialysis (p = 0,00; p < 0,05; r = -0,460) and post hemodialysis (p = 0,03; p < 0,05; r = -0,391). The conclusion in this research is significant relationship between urea level and hemoglobin level for three months doing hemodialysis. Keywords: Anemia, Chronic Kidney Disease, Hemoglobin, Ureum

Item Type: Thesis (S1)
Subjects: MEDICINE > Internal medicine > Specialties of internal medicine
MEDICINE > Internal medicine > Specialties of internal medicine > Diseases of the genitourinary system. Urology
Divisions: FAKULTAS KEDOKTERAN > Pendidikan Dokter
Depositing User: Ms Sari Mentari Simanjuntak
Date Deposited: 21 Apr 2020 02:51
Last Modified: 21 Apr 2020 02:51
URI: http://repository.uki.ac.id/id/eprint/1574

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