Embryo ploidy status classification through computer-assisted morphology assessment

Danardono, Gunawan Bondan and Handayani, Nining and Louis, Claudio Michael and Polim, Arie Adrianus and Sirait, Batara I. and Periastiningrum, Gusti and Afadlal, Szeifoul and Boediono, Arief and Sini, Ivan (2023) Embryo ploidy status classification through computer-assisted morphology assessment. AJOG Global Reports, 3 (3). pp. 1-9. ISSN 2666-5778

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Official URL: https://www.sciencedirect.com/journal/ajog-global-...


BACKGROUND: Preimplantation genetic testing for aneuploidy has been proven to be effective in determining the embryo’s chromosomal or ploidy status. The test requires a biopsy of embryonic cells on day 3, 5, or 6 from which complete information on the chromosomes would be obtained. The main drawbacks of preimplantation genetic testing for aneuploidy include its relatively invasive approach and the lack of research studies on the long-term effects of preimplantation genetic testing for aneuploidy. OBJECTIVE: Computer-assisted predictive modeling through machine learning and deep learning algorithms has been proposed to minimize the use of invasive preimplantation genetic testing for aneuploidy. The capability to predict morphologic characteristics of embryo ploidy status creates a meaningful support system for decision-making before further treatment. STUDY DESIGN: Image processing is a component in developing a predictive model specialized in image classification through which a model is able to differentiate images based on unique features. Image processing is obtained through image augmentation to capture segmented embryos and perform feature extraction. Furthermore, multiple machine learning and deep learning algorithms were used to create prediction- based modeling, and all of the prediction models undergo similar model performance assessments to determine the best model prediction algorithm. RESULTS: An efficient artificial intelligence model that can predict embryo ploidy status was developed using image processing through a his- togram of oriented gradient and then followed by principal component analysis. The gradient boosting algorithm showed an advantage against other algorithms and yielded an accuracy of 0.74, an aneuploid precision of 0.83, and an aneuploid predictive value (recall) of 0.84. CONCLUSION: This research study proved that machine-assisted technology perceives the embryo differently than human observation and determined that further research on in vitro fertilization is needed. The study finding serves as a basis for developing a better computer-assisted prediction model. Key words: artificial intelligence, image processing, in vitro fertilization, noninvasive embryo assessment, preimplantation genetic testing for aneuploid, ploidy status, prediction model

Item Type: Article
Subjects: MEDICINE
Depositing User: Mr Sahat Maruli Tua Sinaga
Date Deposited: 19 Jun 2023 02:43
Last Modified: 26 Jun 2023 09:52
URI: http://repository.uki.ac.id/id/eprint/11610

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