Antihyperlipidemic Activity of Torbangun Extract (Coleus amboinicus Lour) on Diabetic Rats Induced by Streptozotocin

Suryowati, Trini and Rimbawan, Rimbawan and Damanik, Rizal and Bintang, Maria and Handharyani, Ekowati (2015) Antihyperlipidemic Activity of Torbangun Extract (Coleus amboinicus Lour) on Diabetic Rats Induced by Streptozotocin. IOSR Journal Of Pharmacy, 5 (5). pp. 50-54. ISSN 2319 4219

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Abstract

Torbangun (Coleus amboinicus Lour) contains phenolic compounds, especially quercetin which act as antioxidants. This study aims to determine the antihyperlipidemic activity of torbangun leaf ethanol extract in diabetic rats induced by streptozotocin (STZ). Diabetes was induced in Sprague Dawley rats by single intraperitoneal administration of STZ (50mg/kg body weight). Normal as well as diabetic rats were divided into groups (n=5) receiving different treatments. Graded doses 620 mg/kg b.w. (T1) and 930 mg/kg b.w. (T2) of torbangun leaf ethanol extract were studied for a period of 14 days. Metformin hydrocloride (62.5 mg/kg b.w.) and quercetin (15 mg/kg b.w.) were used as a reference drug and antioxidant standart. Oral administration with graded doses T1 and T2 of torbangun leaf ethanol extract exhibited antihyperglycemic and antihyperlipidemic activity in streptozotocin-induced diabetic rats. Data were analyzed with test followed Post-Hoc test with 95% significance level. The daily oral treatment with torbangun leaf ethanol extract showed a significant reduction in blood glucose. There were decreased serum contents of triglycerides and significantly total cholesterol, whereas HDL-cholesterol was increased. Studies clearly demonstrated that torbangun leaf ethanol extract possesses antihyperlipidemic activity in diabettic rats.

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