Growth Factor Make Your Skin Regeneration

Harlim, Ago (2016) Growth Factor Make Your Skin Regeneration. In: Seminar I SWAM 2016, 2-4 Desember 2016, Tangerang.

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Abstract

Growth factors play a key role in the regulation of numerous cell processes including wound healing. More recently, they have been recognized also for use in skin rejuvenation. Aged skin reveals a similarly altered growth factor response as a chronic wound. Growth factors may reduce signs of skin aging due to their capacity to promote dermal fibroblast proliferation and to stimulate extracellular matrix formation. Growth factor products for skin rejuvenation can contain either recombinant growth factors, growth factors as part of conditioned cell culture media, or growth factors as part of cell lysates. Numerous randomized controlled clinical trials demonstrated the good tolerability and efficacy of those products. Today, there is evidence that the signs of aging skin may be best improved with a balanced mixture of growth factors. Chronic sun exposure causes various forms of skin damage. Chronic exposure to solar ultraviolet irradiation can result in facial photoaging such as fine lines and wrinkles, poor texture, and sagging skin. Facial photoaging has become one of the most prevalent aesthetic concerns. New topical formulas can facilitate the skin to repair wrinkles, leading to a younger, healthier looking face and glowing skin. Furthermore, these topical formulas can mitigate further aging by accelerating the synthesis of collagen.An improved understanding of the biochemical mechanisms of skin aging has resulted in the identification of key pathways of intervention to reverse of skin aging.

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