Korelasi Hasil Pemeriksaan C-Reactive Protein dan Laju Endap Darah pada Pasien Positif

Oktaria, Sarah Amira (2021) Korelasi Hasil Pemeriksaan C-Reactive Protein dan Laju Endap Darah pada Pasien Positif. S1 thesis, Universitas Kristen Indonesia.

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Abstract

Pada Desember 2019, ditemukan kasus pneumonia misterius yang pertama kali dilaporkan di Wuhan, Provinsi Hubei. Kemudian dikenal sebagai COVID-19 beserta etiologinya adalah SARS-Cov-2. C-Reactive Protein merupakan protein homopentamerik yang muncul pada kondisi inflamasi. Konsentrasi laju endap darah umum meningkat pada inflamasi akut dan kronis. Tujuan penelitian ini adalah untuk mengetahui korelasi antara konsentrasi CRP dan LED dengan status hasil pemeriksaan diagnostic PCR pada pasien. Jenis penelitian ini adalah studi korelasi dengan pendekatan cross sectional. Data yang diambil adalah hasil pertama kali pemeriksaan PCR dan laboratorium untuk COVID-19. Populasi penelitian ini adalah Pasien dalam pemantauan (PDP) COVID-19 yang berobat di salah satu RS di Bekasi Timur, Jawa Barat. Sampel penelitian ini berjumlah 65 orang, terdiri dari 28 (43,1%) pasien negatif COVID-19 dan 37 (56,9%) pasien positif COVID-19. Hasil penelitian menunjukkan bahwa pada awal pasien melakukan pemeriksaan PCR untuk COVID-19, terdapat peningkatan CRP dengan signifikan lemah (r=0.311), serta terdapat hubungan yang signifikan antara hasil PCR COVID-19 dengan kadar CRP pasien (p=0.040) pada kelompok umur 1-40 tahun. Selain itu, terdapat peningkatan frekuensi pernafasan pada pasien dengan CRP tinggi dengan signifikansi lemah (r=0.366) dan hubungan yang signifikan antara hasil pemeriksaan CRP dengan frekuensi pernafasan pasien (p=0.026). Selain itu, terdapat hubungan yang kuat antara peningkatan CRP dan peningkatan LED (p=0.000) Kata Kunci: COVID-19, SARS-CoV-2, CRP, LED, Frekuensi Pernafasan. / In December 2019, a mysterious pneumonia case was found and was first reported in Wuhan, Hubei Province. Came to be known as COVID-19 with the etiology of SARS-Cov-2. C-Reactive Protein is a homopentameric protein elevated in inflammatory conditions. The erithrocyte sedimentation rate concentration is generally increased in inflammation. The aim of this study was to determine the correlation between CRP and LED concentrations with the status of the PCR diagnostic results in patients. This type of research is a correlation study with a cross sectional approach. The data taken were the results of the first PCR and laboratory examinations for COVID-19. The population of this study were patients under monitoring of COVID--19 who were treated at a hospital in East Bekasi, West Java. The sample of this study were 65 people, consisting of 28 (43.1%) negative COVID-19 patients and 37 (56.9%) positive COVID-19 patients. The results showed that at the beginning of the patient's PCR examination for COVID-19, there was a significantly weak increase in CRP (r = 0.311) and there was a significant relationship between the COVID-19 PCR results and the patient's CRP level (p = 0.040) in the age group of 1-40 years. In addition, there was an increase in respiratory rate in patients with high CRP with weak significance (r = 0.366) and a significant relationship between the results of CRP examination and the patient's respiratory rate (p = 0.026) and a strong significant relationship between the results of CRP and ESR (p = 0.000). Keywords: COVID-19, SARS-CoV-2, CRP, LED, Respiratory Rate

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