Pola Penggunaan Statin di RSU UKI dan Rumah Sakit Khusus Daerah Duren Sawit Tahun 2015-2017

Handayani, Meisy (2018) Pola Penggunaan Statin di RSU UKI dan Rumah Sakit Khusus Daerah Duren Sawit Tahun 2015-2017. S1 thesis, Universitas Kristen Indonesia.

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Abstract

Hiperkolesterolemia adalah suatu kondisi kadar kolesterol di dalam darah melebihi batas normal (>200 mg/dL). Pedoman National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III) merekomendasikan penggunaan statin sebagai obat pilihan pertama untuk menurunkan kadar kolesterol dan LDL dalam darah. Penelitian pola penggunaan statin di dua rumah sakit di Jakarta ditujukan untuk melihat angka responder pasien yang menggunakan statin. Data diambil dari rekam medik dari Januari 2015-Januari 2017 dari setiap rumah sakit. Terdapat 58 kasus dari memenuhi kriteria inklusi, 42 wanita dan 16 pria dengan usia rata-rata dari kedua kelompok yaitu 59  9 (wanita) dan 60  9. Jenis statin yang digunakan dikedua rumah sakit hanya ada dua yaitu Simvastatin dan Atorvastatin. Statin yang sering digunakan adalah Simvastatin (70,7%) diikuti oleh atorvastatin (29,3%). Hanya 23 pasien dengan kadar kolesterol tinggi yang mencapai kadar optimal. Hal tersebut bisa terjadi disebabkan beberapa hal yaitu ketidakpatuhan pasien melakukan pengobatan; pertimbangan biaya obat bagi sebagian orang; evaluasi atau monitoring pengobatan tidak dilakukan secara berkala; pemeriksaan kadar kolesterol tidak dilakukan secara konsisten sehingga tidak diketahui tingkat keberhasilan terapi yang dijalani atau diperlukan penyesuaian dosis atau jenis statin yang dipilih. Maka monitoring dan evaluasi terapi hiperkolesterolemia perlu diperbaiki. Kata Kunci: hiperkolesterolemia, statin. / Hypercholesterolemia is a condition of cholesterol levels in the blood beyond the normal limits (>200 mg / dL). National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III) Guidelines recommends the use of statins as the firstchoice drug to lower cholesterol and LDL levels in the blood. The study of pattern used of statin at two hospitals in Jakarta was aimed to looking at the responder of patients who using statins. Data were taken from the medical records from January 2015- January 2017 from each hospital. There were 58 cases of 127 cases of hypercholesterolemia fulfilling the inclusion criteria, 42 women and 16 men with mean age of both groups of 59 9 (women) and 60  9. Type of statin that used in both hospitals were only Simvastatin and Atorvastatin. The frequently used statins are Simvastatin (70.7%) followed by atorvastatin (29.3%). Only 23 patients with high cholesterol levels reached optimal levels. This can happen due to several things, noncompliance of patients in the treatment; consideration of drug costs for some people; treatment evaluation or monitoring is not performed regularly; examination of cholesterol levels is not done consistently so that the success rate of therapy is unknown or required adjustment of dose or type of statins selected. So monitoring and evaluation of hypercholesterolemia therapy needs to be improved. Keywords: hypercholesterolemia, statin.

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