Uji Aktivitas antifungi ekstrak Andaliman (Zanthoxylum Acanthopodium DC) terhadap Candida Albicans

Bavelina, Irene Rumiris (2019) Uji Aktivitas antifungi ekstrak Andaliman (Zanthoxylum Acanthopodium DC) terhadap Candida Albicans. S1 thesis, Universitas Kristen Indonesia.

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Abstract

Andaliman (Zanthoxylum acanthopodium DC) adalah salah satu tumbuhan khas yang banyak tumbuh dan dimanfaatkan di Sumatera, terutama oleh suku Batak di Sumatera Utara. Secara empiris andaliman digunakan oleh masyarakat untuk pengobatan diare, sakit gigi, dan mengawetkan makanan (antimikroba). Penelitian yang dilakukan bertujuan untuk mengetahui potensi ekstrak andaliman dalam menghambat pertumbuhan Candida albicans serta mengetahui kandungan senyawa fitokimianya. Proses ekstraksi menggunakan metode maserasi dengan pelarut etanol 70% dan akuades. Metode uji aktivitas antifungi yang digunakan adalah metode difusi cakram dan uji fitokimia dengan metode Harborne. Konsentrasi ekstrak andaliman yang digunakan yaitu 50%,40%,30%,20% dan 10%, dengan kontrol positif berupa flukonazol dan kontrol negatif adalah akuades. Hasil penelitian menunjukkan bahwa ekstrak andaliman baik dengan pelarut etanol maupun akuades mempunyai efek antifungi terhadap pertumbuhan Candida albicans dengan konsentrasi terendah sebesar 10%. Ekstrak andaliman mengandung senyawa aktif berupa flavonoid, tanin, saponin, dan steroid. Kata kunci: Andaliman, antifungi, Candida albicans, fitokimia. / Andaliman (Zanthoxylum acanthopodium DC) is one of the typical plants that is widely grown and utilized in Sumatra, especially by the Batak tribe in North Sumatra. Empirically andaliman is used by people for the treatment of diarrhea, toothache, and preserving food (antimicrobial). The research conducted aims to determine the potential of andaliman extracts in inhibiting the growth of Candida albicans and to find out the phytochemical compounds. The extraction process uses maceration method with 70% ethanol solvent and aquadest. The antifungal activity test method used is the disc diffusion method and phytochemical test with the Harborne method. Andaliman extract concentrations used are 50%, 40%, 30%, 20% and 10%, with positive control in the form of fluconazole and negative control is aquadest. The results showed that the Andaliman extract both with ethanol and aquadest had an antifungal effect on the growth of Candida albicans with the lowest concentration of 10%. Andaliman extract contains active compounds in the form of flavonoids, tannins, saponins, and steroids. Keywords: Andaliman, Antifungi, Candida albicans, phytochemicals.

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