Uji Efektivitas Ekstrak Etanol Daun Afrika terhadap Bakteri Salmonella Typhi

Bakujai, Esther Elisabeth (2019) Uji Efektivitas Ekstrak Etanol Daun Afrika terhadap Bakteri Salmonella Typhi. S1 thesis, Universitas Kristen Indonesia.

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Abstract

Salmonella typhi merupakan bakteri gram negatif yang bersifat patogen yang menyebabkan penyakit infeksi yang berbahaya. Bakteri tersebut resisten terhadap hampir semua antibiotik seperti penisilin, kloramfenikol, dan metisilin. Masalah resisten telah menjadi masalah global sehingga dibutuhkan bahan antibakteri baru yang dapat yang dapat menghambat pertumbuhan Salmonnela typhi. Salah satu tumbuhan yang berasal dari benua Afrika, digunakan sebagai obat – obatan untuk mengobati diare, diabetes dan malaria. Dimana dari penelitian sebelumnya daun afrika mengandung anthraquinone dan phobatanin yang dapat menghambat pertumbuhan bakteri patogen. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri ekstrak daun afrika terhadap pertumbuhan Salmonella typhi. Penelitian ini merupakan penelitian eksperimental dengan menggunakan konsentrasi ekstrak daun afrika 10%, 20%, 40%, 60%, 80%, dan 100%. Uji aktivitas antibakteri berdasarkan adanya zona hambat yang terbentuk. Hasil penelitian menunjukan adanya perbedaan zona hambat antar perlakuan konsentrasi ekstrak terhadap pertumbuhan bakteri Salmonella typhi, pada konsentrasi 100 dapat dilihat terbentuknya zona hambat dengan diameter paling besar 10,17mm dan pada konsentrasi 20% hanya terbentuk zona hambat dengan diameter 6,55mm. Aktivitas antibakteri yang dimiliki daun afrika tidak mampu menghambat pertumbuhan bakteri Salmonella typhi dan tidak terbentuk zona hambatan. Kata kunci : antibakteri,daya hambat, flavonoid, ekstrak. / Salmonella typhi is a gram negative bacterium that is pathogenic which causes a dangerous infectious disease. The bacteria are resistant to almost all antibiotics such as penicillin, chloramphenicol, and methicillin. The problem of resistance has become a global problem so that new antibacterial materials can be used which can inhibit the growth of Salmonella typhi. One of the plants originating from the continent of Africa, is used as a drug - medicine to treat diarrhea, diabetes and malaria. Where from previous studies African leaves contain anthraquinones and phobatanins which can inhibit the growth of pathogenic bacteria. This study aims to determine the antibacterial activity of African leaf extract on the growth of Salmonella typhi. This research is an experimental study with treatment of variations in the concentration of african leaf extract. Antibacterial activity test based on the presence of a formed inhibition zone. The results showed that there were differences in the inhibition zone between the treatment of extract concentrations against the growth of Salmonella typhi bacteria, at a concentration of 100 can be seen the formation of inhibition zones with the largest diameter 10,17mm and at a concentration of 20% only formed a zone of inhibition with a diameter of 6,55mm. The antibacterial activity possessed by african leaves cannot inhibit the growth of Salmonella typhi bacteria not due to the formation of a zone of resistance. Key word : antibacterial, inhibition, flavonoids, extract

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