Analisis Kadar Hemoglobin Tikus Putih Betina (Rattus Norvegicus) Sebelum dan Pasca Intervensi Ekstrak Daun Sirih (Piper Betle L.)

Ginting, Peni Miranda (2019) Analisis Kadar Hemoglobin Tikus Putih Betina (Rattus Norvegicus) Sebelum dan Pasca Intervensi Ekstrak Daun Sirih (Piper Betle L.). S1 thesis, Universitas Kristen Indonesia.

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Abstract

Tujuan Penelitian : Untuk menganalisis efek penggunaan ekstrak daun sirih terhadap kadar hemoglobin (Hb) pada tikus putih betina. Metode penelitian : Penelitian eksperimental laboratorik dengan desain Pre and Post Control Group Randomize dilakukan pada 24 ekor tikus betina dewasa yang memenuhi kriteria inklusi. Tikus dibagi menjadi 4 kelompok : K1 (Kontrol), K2 (dosis 2,5 gr), K3 (dosis 10 gr), K4 (dosis 15 gr). Kadar Hb diperiksa secara serial (sebelum intervensi , 7 hari dan 14 hari pasca intervensi. Hasil : Terdapat penurunan kadar Hb yang tidak bermakna pasca7 hari intervensi : K1(14,73±0,48), K2 (14,86±0,92), K3 (14,13±0,53), dan K4 (13,83±0,56). Terdapat penurunankadar Hb yang tidak bermakna pasca 14 hari intervensi : K1 (14,71±0,82), K2 (14,48±0,39), K3 (13,93±0,77), dan K4 (13,78±0,57), namun didapatkan penurunan yang bermakna diantara kelompok penelitian. Kesimpulan : Terdapat korelasi negatif yang cukup kuat dan bermakna antara penurunan kadar hemoglobin (Hb) dengan pemberian ekstrak daun sirih selama 14 hari. Kata kunci : Daun sirih, Hemoglobin, Tikus. Objective: To analyze the effect of using Piper betle L. extract on hemoglobin (Hb) levels in female white rats. Methods: A laboratory experimental study with the design of Pre and Post Control Group Randomize was performed on 24 adult female rats that met the inclusion criteria. Rats were divided into 4 groups: K1 (Control), K2 (dose 2.5 gr), K3 (dose 10 gr), K4 (dose 15 gr). Hb levels were examined serially (before intervention, 7 days and 14 days post intervention). Results: There was no significant decrease in Hb levels after 7 days of intervention: K1 (14,73±0,48), K2 (14,86±0,92), K3 (14,13±0,53), and K4(13,83±0,56). There was no significant decrease in Hb levels after 14 days of intervention: K1 (14,71±0,82), K2 (14,48±0,39), K3 (13,93±0,77and K4 (13,78±0,57), but there was a significant decrease among the study groups. Conclusion: There is a strong and significant negative correlation between a decrease in hemoglobin level (Hb) with intervention of Piper betle L. extract for 14 days. Keywords:Piper betle L., Hemoglobin, Rat.

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