Efektivitas Penggunaan Aspirin dan Asam Folat dalam Pencegahan Preeklampsia: Sebuah Tinjauan Sistematis dan Meta-Analisis

Elena, Elena (2023) Efektivitas Penggunaan Aspirin dan Asam Folat dalam Pencegahan Preeklampsia: Sebuah Tinjauan Sistematis dan Meta-Analisis. S1 thesis, Universitas Kristen Indonesia.

	Text (Hal_Judul_Daftar_Isi_Daftar_Tabel_Daftar_Gambar_Abstrak) HalJudulDaftarIsiDaftarTabelDaftarGambarAbstrak.pdf Available under License Creative Commons Attribution Non-commercial Share Alike. Download (1MB)
	Text (BAB_I) BABI.pdf Available under License Creative Commons Attribution Non-commercial Share Alike. Download (151kB)
	Text (BAB_II) BABII.pdf Restricted to Registered users only Available under License Creative Commons Attribution Non-commercial Share Alike. Download (602kB)
	Text (BAB_III) BABIII.pdf Restricted to Registered users only Available under License Creative Commons Attribution Non-commercial Share Alike. Download (259kB)
	Text (BAB_IV) BABIV.pdf Restricted to Registered users only Available under License Creative Commons Attribution Non-commercial Share Alike. Download (305kB)
	Text (BAB_V) BABV.pdf Restricted to Registered users only Available under License Creative Commons Attribution Non-commercial Share Alike. Download (72kB)
	Text (Daftar_Pustaka) DaftarPustaka.pdf Available under License Creative Commons Attribution Non-commercial Share Alike. Download (195kB)

Abstract

Tujuan: Penelitian ini bertujuan untuk mengetahui efektivitas penggunaan aspirin dan asam folat pada kelompok ibu hamil dengan risiko tinggi preeklampsia sebagai pencegahan preeklampsia. Metode: Tinjauan sistematis dan meta-analisis kuantitatif untuk mengetahui efektivitas penggunaan aspirin dan asam folat pada kelompok ibu hamil dengan risiko tinggi PE sebagai pencegahan preeklampsia. Penelitian ini mengikuti protokol Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA). Sumber Data: PubMed, Google Scholar, Plos One, Science Direct, dan Research Gate. Hasil: 17 Jurnal memenuhi kriteria. Terdapat 14 jurnal penelitian membahas mengenai aspirin sebagai pencegahan preeklampsia, dan 3 jurnal penelitian membahas asam folat sebagai pencegahan preeklampsia pada kelompok risiko tinggi PE. Hasil meta-analisis pada penelitian aspirin, menunjukan aspirin direkomendasikan untuk menurunkan kejadian preeklampsia pada kelompok risiko tinggi preeklampsia (RR 0.83 [95% CI: 0.78, 0.88], P<0.00001). Didapatkan homogen (I2=43%, P=0.03). Pemberian aspirin dengan dosis yang bermakna dalam menurunkan kejadian preeklampsia adalah dosis 50 mg/hari (RR 0.56 [95% CI: 0.36, 0.86] P=0.008), 60 mg/hari (RR 0.87 [95% CI: 0.81, 0.93] P<0.0001), 75 mg/hari (RR 0.54 [95% CI: 0.40, 0.73] P<0.0001), 80-81 mg/hari (RR 0.72 [95% CI: 0.56, 0.94] P=0.02), 150 mg/hari (RR 0.66 [95% CI: 0.50, 0.88] P=0.004). Hasil meta-analisis pada penelitian asam folat, didapatkan hasil asam folat tidak direkomendasikan untuk menurunkan kejadian preeklampsia pada kelompok risiko tinggi PE (RR 1.33 [95% CI: 0.76, 2.33], P=0.31). Didapatkan heterogenitas (I2=53%, P=0.12). Kesimpulan: Pemberian aspirin sangat direkomendasikan untuk menurunkan angka kejadian PE, dengan rekomendasi dosis terbaik adalah 75 mg/hari. Sedangkan, pemberian asam folat pada kelompok risiko tinggi preeklampsia tidak direkomendasikan sebagai pencegahan Preeklampsia. Kata Kunci: Efektivitas, Aspirin, Asam Folat, Pencegahan Preeklampsia. / Objective: This study aims to determine the effectiveness of using aspirin and folic acid in a group of pregnant women with a high risk of preeclampsia as preventive measures. Method: Systematic review and meta-analysis quantitative to determine the effectiveness of using aspirin and folic acid in a group of pregnant women at high risk of PE as prevention of preeclampsia. This study followed a protocol called Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA). Data sources: PubMed, Google Scholar, Plos One, Science Direct, and Research Gate. Results: 17 journals meet the criteria. There are 14 research journals discussing aspirin as a prevention of preeclampsia and 3 research journals discussing folic acid as a prevention of preeclampsia in high-risk groups for PE. The results of a meta-analysis on aspirin research showed that aspirin is recommended to reduce the incidence of preeclampsia in the high-risk group for preeclampsia (RR 0.83 [95% CI: 0.78, 0.88], P<0.00001). Obtained homogeneity (I2=43%, P=0.03). Giving aspirin at a significant dose reduced the incidence of preeclampsia by 50 mg/day (RR 0.56 [95% CI: 0.36, 0.86] P=0.008), 60 mg/day (RR 0.87 [95% CI: 0.81, 0.93] P <0.0001), 75 mg/day (RR 0.54 [95% CI: 0.40, 0.73] P<0.0001), 80-81 mg/day (RR 0.72 [95% CI: 0.56, 0.94] P=0.02), and 150 mg/day (RR 0.66 [95% CI: 0.50, 0.88] P=0.004). The results of a meta-analysis on folic acid research showed that folic acid was not recommended for reducing the incidence of preeclampsia in the high-risk group for PE (RR 1.33 [95% CI: 0.76, 2.33], P=0.31). Heterogeneity was found (I2=53%, P=0.12). Conclusion: Giving aspirin is highly recommended to reduce the incidence of PE, with the best recommended dose being 75 mg/day. Meanwhile, giving folic acid to groups at high risk of preeclampsia is not recommended as prevention of preeclampsia. Keywords: Effectiveness, Aspirin, Folic Acid, Prevent Preeclampsia

Actions (login required)

View Item