Systematic Review of The Effect of Vitamin D Supplementation on Immune Response

Indrawati, Lili and Purwantyastuti, Purwantyastuti and Abikusno, Nugroho (2011) Systematic Review of The Effect of Vitamin D Supplementation on Immune Response. Majalah Kedokteran Indonesia, 61 (8). ISSN 0377 1121

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Abstract

The potential role for vitamin D and its active metabolite 1, 25-hydroxyvitamin D (1,25(OH)2D) in modulating the immune response was first recognized 25 years ago. The presence of adequate levels of vitamin D is required for the proper functioning of the body’s defense system such as barrier integrity, the production of antimicrobials, chemotaxis of other immune cells and regulation of inflammation in the innate and adaptive immune system. We identified 60 studies on vitamin D and immune response. A total of 33 studies were excluded because it was not clinical trials, of the remaining 27, 21 were excluded because clinical trials were not randomized controlled trials and one was excluded because of using combined vitamin D and calcium, so the remaining five clinical trials were reviewed to evaluate the clinical evidence for the role of vitamin D in the immune system. From the five Randomized Controlled Trials (RCTs) were reviewed in this paper, it is concluded that the results from these studies appear quite robust and consistent. Side effect profile of vitamin D preparations were minimal and rare as indicated by reports of post marketing surveilence as well as RCTs.

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