In Vitro Anticancer Activity of Leaves Extracts from Annona muricata againts HeLa Cervical Cancer Cell Line

Indrawati, Lili and Rahardjo, Tri Budi W. and Agustin, Dinni and Meilany, Sofy and Winarno, M. Wien (2013) In Vitro Anticancer Activity of Leaves Extracts from Annona muricata againts HeLa Cervical Cancer Cell Line. In: The 18th Busan Active Aging Conference in Asia Pacific, 27-06-2013, Busan.

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Abstract

Cervical cancer continues to be a widespread public health problem in women worldwide especially in developing country like Indonesia. The data from thirteen pathology centers in Indonesia describes that cervical cancer stands the first-ranked among all cancer. The soursop (Annona muricata) is a traditional medicinal plant which is empirically used by the people of Indonesia for anti-inflammation and anti-tumor. This study aims to determine the cytotoxic effects from extracts of leaves of soursop in cervical cancer cells HeLa. Method: The research was carried out by extraction using ethanol and water. Cytotoxic test performed by the method of MTT assay. The parameters obtained from the cytotoxic test was IC50 values, ie concentrations that produce inhibitory of cancer cells by 50%. Result: The results showed that the ethanol extracts of soursop leaves has a cytotoxic activity with IC50 values of 1,787μg / mL, while aquos extracts the leaves has cytotoxic activity with IC50 values of 1,781 μg / mL. All that values is better than that obtained from 5-Fluorouracil with IC50 values of 1,82 μg/mL.

Item Type: Conference or Workshop Item (Paper)
Subjects: MEDICINE > Internal medicine > Neoplasms. Tumors. Oncology Including cancer and carcinogens
Depositing User: Edi Wibowo
Date Deposited: 03 Dec 2018 09:02
Last Modified: 03 Dec 2018 09:02
URI: http://repository.uki.ac.id/id/eprint/472

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