The Effects Of Body Mass Index And Atherogenic Index On Retinal Microvascular Structure In Obese Patients

UNSPECIFIED The Effects Of Body Mass Index And Atherogenic Index On Retinal Microvascular Structure In Obese Patients. International Ophthalmology. (Unpublished)

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Abstract

Purpose: This study aimed to evaluate the ocular alterations especially on retinal microvasculature of obese patients and to determine the association of these alterations with clinical features. Material and Methods: Height, body weight, blood lipid and glucose levels were recorded in all patients. BMI was calculated.In all participants, biochemical examinations were performed including cholesterol levels, fasting blood glucose, fasting insulin,CRP,Hb A1C levels.The atherogenic index of plasma was calculated as a logarithm of the ratio of the molar concentration (mmol/l) of TG to HDL-C (log [TG/HDL-C]).Patients with a BMI ≤ 25 kg/m 2 were included in the control group. Obese patients were sub-grouped into 3 according to their BMI as group 1 (BMI between 30-34.99 kg/m 2 ), group 2 (BMI between 35-39.99 kg/m 2 ), and group 3 (BMI ≥ 40 kg/m 2 ).The macular and peripapillary thicknesses were measured using an SD-OCT device. The foveal avascular zone (FAZ), the vessel density (VD) of the superficial capillary plexus and deep capillary plexus of the macula, and the VD of the retinal peripapillary capillary plexus (RPCP) for the optic disc were quantified by OCTA. Results: Totally 110 patients, 27 control cases,and 83 obese patients were included in the study. There was not any significant difference between four groups regarding the gender (p= 0.192). HbA1C, fasting insulin,HOMA-IR,CRP,AI levels were significantly higher in obese patients compared with the control cases. Superficial (p= 0.003) and deep (p= 0.001) VD’s of retina significantly decreased and FAZ significantly increased (p= 0.032) in obese patients. In correlation analysis performed between the clinical features and OCT-A findings, the superficial and deep vessel densities inversely correlated with age, BMI, Hb A1C, and AI. Conclusion: Retinal superficial and deep vessel densities are decreased in obese patients and there was an inverse relationship between the retinal vessel densities and age, BMI, Hb A1C, and AI.

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