Analysis of Anti‑toxoplasma Immunoglobulin G and Immunoglobulin M Antibody Levels after Intervention with Curcuma Longa Extract on Early Pregnant Mice with Acute Toxoplasmosis

Simanjuntak, Tigor Peniel and Hatta, Mochammad and Tahir, Andi Mardiah and Sirait, Robert Hotman and Karo, Marni Br and Tambaip, Titus and Dwiyanti, Ressy and Noviyanthi, Rizki Amelia and Junita, Ade Rifka (2019) Analysis of Anti‑toxoplasma Immunoglobulin G and Immunoglobulin M Antibody Levels after Intervention with Curcuma Longa Extract on Early Pregnant Mice with Acute Toxoplasmosis. Journal of Global Infectious Diseases, 11 (1). pp. 25-29. ISSN 0974 777X

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Abstract

Background: Curcuma longa has strong anti‑inflammatory effect. This study aims to evaluated the level of anti‑Toxoplasma immunoglobulin G and immunoglobulin M (IgG‑IgM) antibody after intervention with C. longa extract in early pregnant mice with acute toxoplasmosis. Materials and Methods: We evaluated 20 early pregnant mice that were divided into five groups, four mice in each. Group 1‑4 received injections of Toxoplasma gondii tachyzoites. Three days later, G1 and G2 were given orally 125 mg/kg/day and 500 mg/kg/day of C. longa extract, respectively. G3 was given 60 mg/kg/day of spiramycin (positive control), and G4 was given 0.2 ml of distilled water (negative control). G5 underwent no intervention at all. Blood samples were obtained serially (before and 3 days after injection of tachyzoites, 3 days and 7 days after intervention) to assess anti‑Toxoplasma IgG‑IgM antibody levels by enzyme‑linked immunosorbent assay methods. Results: Anti‑Toxoplasma IgG‑IgM antibody levels increased significantly 3 days after injection of tachyzoites (P < 0.05), but decreased significantly (P < 0.05) 3 days, and 7 days after administration of C. longa extract dose 125 mg, 500 mg, and spiramycin 60 mg, and there was no significant difference between these three groups. Anti‑Toxoplasma IgG‑IgM antibody levels increased significantly (P < 0.05) 3 days, 6 days, and 10 days after injections of tachyzoites on G4. The IgG‑IgM antibody levels fluctuated on G5 and considered as insignificant (P > 0.05). Conclusion: The administration of C. longa extract at a dose of 125 mg/kg/day for 7 days effectively decreased anti‑Toxoplasma IgG‑IgM antibody level in early pregnant mice with acute toxoplasmosis.

Item Type: Article
Subjects: MEDICINE
Depositing User: Edi Wibowo
Date Deposited: 22 Oct 2020 08:38
Last Modified: 15 Jan 2021 07:15
URI: http://repository.uki.ac.id/id/eprint/2701

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