A novel diagnosis scoring model to predict invasive pulmonary aspergillosis in the intensive care unit

Rozaliyani, Anna and Sedono, Rudyanto and Jusuf, Anwar and Rumende, Cleopas M. and Aniwidyaningsih, Wahju and Burhan, Erlina and Prasenohadi, and Handayani, Diah and Yunihastuti, Evy and Siagian, Forman Erwin and Jayusman, Achmad M. and Rusli, Adria and Sungkar, Saleha and Prihartono, Joedo and Hagen, Ferry and Meis, Jacques F. and Wahyuningsih, Retno (2019) A novel diagnosis scoring model to predict invasive pulmonary aspergillosis in the intensive care unit. Saudi Medical Journal, 40 (2). pp. 140-146. ISSN 1658 3175

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Abstract

Objectives: To improve the quality of invasive pulmonary aspergillosis (IPA) management for intensive care unit (ICU) patients using a practical diagnostic scoring model. Methods: This nested case-control study aimed to determine the incidence of IPA in 405 ICU patients, between July 2012 and June 2014, at 6 hospitals in Jakarta, Indonesia. Phenotypic identifications and galactomannan (GM) tests of sera and lung excreta were performed in mycology laboratory, Parasitology Department, Faculty of Medicine, Universitas Indonesia in Jakarta, Indonesia. Results: The incidence of IPA in the ICUs was 7.7% (31 of 405 patients). A scoring model used for IPA diagnosis showed 4 variables as the most potential risk factors: lung excreta GM index (score 2), solid organ malignancy (score 2), pulmonary tuberculosis (score 2), and systemic corticosteroids (score 1). Patients were included in a high-risk group if their score was >2, and in a low-risk group if their score was <2. Conclusion: This study provides a novel diagnosis scoring model to predict IPA in ICU patients. Using this model, a more rapid diagnosis and treatment of IPA may be possible. The application of the diagnosis scoring should be preceded by specified pre-requisites.

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