Effectiveness of Aspirin Dose in Preventing Preeclampsia in High-Risk Group: A Meta-Analysis

Simanjuntak, Tigor Peniel and Elena, Elena and Sirait, Batara I. (2025) Effectiveness of Aspirin Dose in Preventing Preeclampsia in High-Risk Group: A Meta-Analysis. Indonesian Journal of Obstetrics & Gynecology Science, 8 (2). pp. 398-407. ISSN 2615-496X

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Abstract

impaired function of the mother’s organs or the uteroplacental unit. Purpose: To evaluate the efficacy of aspirin doses in preventing preeclampsia in high-risk populations. Method: This study follows the PRISMA protocol. The reviewers examined all the findings and selected studies that met the inclusion criteria and PICO analysis. Statistical analysis was performed using Review Manager 5.4 software. A total of 14 journals met the inclusion criteria with searches in four databases (PubMed, Science Direct, Google Scholar, and Plos One). Result: Aspirin significantly reduced the incidence of preeclampsia in the high-risk group (RR 0.83 [95% CI: 0.78, 0.88], P<0.00001), reducing the incidence of preeclampsia by 50 mg/day (RR 0.56 [95% CI: 0.36, 0.86] P=0.008), 60 mg/day (RR 0.87 [95% CI: 0.81, 0.93] P <0.0001), 75 mg/day (RR 0.54 [95% CI: 0.40, 0.73] P<0.0001), 80-81 mg/day (RR 0.72 [95% CI: 0.56, 0.94] P=0.02), and 150 mg/day, reduced the incidence of PE (P<0.00001). Conclusion: The results of the study show that the best dose of aspirin to prevent PE in high-risk groups is 75 mg/ day. Keywords: aspirin; dose; effectiveness; pre-eclampsia; prevention.

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