NEUTROPHIL-LYMPHOCYTE COUNT RATIO IN BACTERIAL SEPSIS

Luhulima, Danny Ernest Jonas and Marwito, and O, Eva (2017) NEUTROPHIL-LYMPHOCYTE COUNT RATIO IN BACTERIAL SEPSIS. INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY, 23 (3). pp. 157-262. ISSN 4277 4685

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Abstract

Sepsis due to bacterial infection is a matter of very serious medical emergency and requires prompt and proper handling. Various parameters such as CRP (C-reactive protein) and PCT (procalcitonin) levels are used as a marker of sepsis due to bacterial infection. Sepsis is a condition of systemic inflammation with infection. Physiological response to systemic inflammation determines increased the level of neutrophil and reduction of lymphocyte count, therefore combining both of parameters could be a marker in predicting sepsis. The aim of this research was to determine the sensitivity and specificity of the NLCR test in patient with sepsis due to bacterial infection. This research was conducted by observing 70 SIRS patients aged 14–70 years, at Mitra Keluarga Bekasi Timur Hospital and Faculty of Medicine Universitas Kristen Indonesia (UKI) Hospital in July-September 2015. This research was an observational comparative study with cross-sectional design. Based on ROC curve showed that NLCR test has a sensitivity of 97.8% and specificity of 84.0%, with cut off ≥6.4 (AUC: 0.94, p value <0.05). In conclusion, the NLCR is an ideal and efficient marker to diagnose sepsis due to bacterial infection with good sensitivity and specificity.

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