Korelasi Peningkatan Kadar High Fluorescent Lymphocyte Count pada Pasien Covid-19

Luhulima, Wisnu Satrio Erangga (2021) Korelasi Peningkatan Kadar High Fluorescent Lymphocyte Count pada Pasien Covid-19. S1 thesis, Universitas Kristen Indonesia.

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Abstract

Pada akhir Desember 2019, terdapat suatu penyakit baru yang disebabkan oleh coronavirus jenis baru yaitu Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), penyakit ini dinamankan sebagai Coronavirus Disease 2019 (COVID-19). High fluorescent lymphocyte count (HFLC) adalah suatu metode pemeriksaan hematologi dengan menggunakan alat analisis hematologi otomatis. Perhitungan dari HFLC didasarkan pada intensitas fluoresensi tinggi yang digunakan sebagai penanda dari limfosit atipikal. Peningkatan dari kadar HFLC merupakan indikasi respon imun terhadap suatu penyakit infeksi. Tujuan penelitian ini adalah untuk mengetahui korelasi peningkatan HFLC pada pasien terkonfirmasi positif COVID-19. Jenis penelitian ini adalah studi korelasi dengan pendekatan cross sectional. Data yang diambil adalah hasil pertama kali pemeriksaan PCR dan laboratorium darah untuk COVID-19. Populasi penelitian ini adalah pasien dalam pemantauan (PDP) Covid-19 yang berobat di salah satu RS di Bekasi Timur, Jawa Barat. Sampel penelitian ini berjumlah 69 orang (29 orang negatif COVID-19 dan 40 orang positif COVID-19). Hasil penelitian menunjukan bahwa pada awal pasien melakukan pemeriksaan PCR untuk COVID-19 tidak terjadi peningkatan HFLC yang signifikan (r = 0.154) serta, tidak ada hubungan yang signifikan antara hasil PCR COVID-19 dengan kadar HFLC pasien (P = 0.207). Kata Kunci: COVID-19, HFLC, Limfosit reaktif, Limfosit atipikal. / At the end of December 2019, there is a new disease caused by a new type of coronavirus, namely Severe Acute Respiratory Syndrome Coronavirus-2 (SARSCoV-2), it was named Coronavirus Disease 2019 (COVID-19). High fluorescent lymphocyte count (HFLC) is a method of hematology examination using an automated hematoanlyzer. The calculation of the HFLC is based on the high fluorescence intensity used as a marker for atypical lymphocytes. An increase in HFLC levels is an indication of an immune response to an infectious disease. The aim of this study was to determine the correlation of increased HFLC in patients confirmed positive for COVID-19. This type of research is a correlation study with a cross sectional approach. The data taken are the first results of PCR and laboratory examinations for COVID-19. The population of this study were patients under monitoring (PDP) COVID-19 who were treated at one of the hospitals in East Bekasi, West Java. The research sample consisted of 69 people (29 people who were negative for COVID-19 and 40 people were positive for COVID-19). The results showed that at the beginning of the patient's PCR examination for COVID-19, there was no significant increase in HFLC (r = 0.154) and there was no significant relationship between the PCR result of COVID-19 and the patient's HFLC level (P = 0.207). Keywords: COVID-19, HFLC, Reactive Lymphocytes, Atypical Lymphocytes

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