Efikasi Povidone Iodine 5% Dibandingkan dengan Tetes Telinga Antibiotik pada Tatalaksana Pasien Otitis Media Supuratif Kronik: Telaah Sistematis dan Meta Analisis

Kusumawati, Dyah Sari (2021) Efikasi Povidone Iodine 5% Dibandingkan dengan Tetes Telinga Antibiotik pada Tatalaksana Pasien Otitis Media Supuratif Kronik: Telaah Sistematis dan Meta Analisis. S1 thesis, Universitas Kristen Indonesia.

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Abstract

Latar belakang: Povidone iodine (PVP – I) adalah antiseptik yang dikenal dapat membunuh atau menghambat pertumbuhan mikroorganisme, banyak tersedia diberbagai negara dan relatif murah. PVP-I 5% dinyatakan aman dalam beberapa penelitian akan tetapi efikasi sebagai obat tetes telinga dalam tatalaksana Otitis Media Supuratif Kronik (OMSK) belum ada kejelasan. Adanya masalah perubahan pola kepekaan kuman terhadap antibiotik dan biaya pengobatan cukup mahal, dirasa perlu dilakukan penelitian untuk membandingkan efikasi tetes telinga PVP – I 5% dengan tetes telinga antibiotik dalam tatalaksana OMSK. Metode: Penelitian ini menggunakan telaah sistematis dan meta analisis. Pencarian literatur Randomized Controlled Trial efikasi tetes telinga PVP – I 5% dibandingkan dengan tetes telinga antibiotik dalam tatalaksana OMSK dari database PubMed, Springerlink, Cochrane dan Google Scholar. Data yang dikumpulkan adalah angka kesembuhan. Hasil: Teridentifikasi 407 artikel penelitian, setelah dilakukan penyaringan tersisa 24 literatur. Akhir penyaringan tersisa 2 literatur kemudian dilakukan review menghasilkan 2 literatur untuk dianalisis. Analisis gabungan nilai risiko relatif (RR) kesembuhan kedua penelitian adalah 1,06 (95% CI: 0,86 - 1,30), nilai Z=0,54 dan p=0,59 (>0,05) sehingga baik secara klinis ataupun secara statistik tidak ada perbedaan bermakna kesembuhan penderita OMSK setelah diberikan tetes telinga Povidone Iodine 5% dibandingkan dengan tetes telinga antibiotik. Simpulan: Penggunaan tetes telinga Povidone Iodine 5% dan tetes telinga antibiotik memiliki efikasi yang sama baiknya dalam tatalaksana OMSK. Perlu evidence lebih banyak tentang tetes telinga PVP-I 5% dalam tatalaksana OMSK. Kata Kunci: Otitis media supuratif kronis, povidone iodine, tetes telinga, terapi. / Background: Povidone iodine is an antiseptic known to kill or inhibit the growth of microorganisms, widely available in various countries and relatively cheap. 5% Povidone iodine is safe in several studies, but the efficacy as ear drops in the management of CSOM is not clear. There is a problem of changing the pattern of sensitivity of germs to antibiotics and the cost of treatment is quite expensive, it is necessary to conduct a study to compare the efficacy of 5% povidone iodine ear drops with antibiotic ear drops in the treatment of CSOM. Methods: This study used a systematic review and meta-analysis. A literature search for Randomized Controlled Trial the efficacy of 5% povidone iodine ear drops compared with antibiotic ear drops in the management of CSOM from the PubMed, Springerlink, Cochrane and Google Scholar databases. The data collected is the cure rate. Results: Identification of 407 research articles, after screening the remaining 24 literatures. At the end of screening, the remaining 2 literatures were then conducted a review to inlcude 2 literature for analysis. The analysis of the relative risk value (RR) of recovery in the two studies was 1.06 (95% CI: 0.86-1.30), the Z value = 0.54 and p = 0.59 (> 0.05). Therefore, both clinically and statistically there was no significant difference in the recovery of CSOM sufferers after being given 5% Povidone Iodine ear drops compared to antibiotic ear drops. Conclusion: The use of 5% povidone iodine ear drops and antibiotic ear drops have the same efficacy in the management of CSOM. More evidence is needed regarding PVP-I 5% ear drops in the management of CSOM. Key Words: Chronic supurative otitis media, povidone iodine, ear drops, therapy

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