Pengaruh Pemberian Kopi Robusta (Coffea Canephora) Green Bean Terhadap Gambaran Histopatologi Gaster Mencit (Mus Musculus) yang Telah Diinduksi Aspirin

Lidesia, Chelsy (2021) Pengaruh Pemberian Kopi Robusta (Coffea Canephora) Green Bean Terhadap Gambaran Histopatologi Gaster Mencit (Mus Musculus) yang Telah Diinduksi Aspirin. S1 thesis, Universitas Kristen Indonesia.

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Abstract

Kopi telah menjadi tren di kalangan masyarakat dunia, termasuk Indonesia. Kopi juga mulai digunakan sebagai obat alternatif beberapa penyakit. Kopi mengandung senyawa aktif seperti polifenol dan alkaloid yang terkenal sebagai antioksidan. Salah satu kopi yang paling banyak di Indonesia adalah kopi robusta (Coffea canephora). Penelitian sebelumnya membuktikkan kopi robusta dapat mempercepat penyembuhan luka. Penelitian ini bertujuan untuk mengetahui aktivitas gastroprotektif kopi robusta (Coffea canephora) green bean terhadap gambaran histopatologi gaster mencit (Mus musculus) yang telah diinduksi aspirin. Penelitian ini adalah penelitian eksperimental laboratium dengan rancangan posttest dengan kelompok kontrol. Ada 4 kelompok yang masing-masing berisi 6 ekor mencit. Mencit pada Kelompok Kontrol (KK) hanya diberi pakan dan akuades, Kelompok Perlakuan 1 (KP1) diberi kopi 0,1 g/hari, Kelompok Perlakuan 2 (KP2) diberi aspirin 10 g/hari, dan Kelompok Perlakuan 3 (KP3) diberi aspirin 10 g/hari lalu diikuti kopi 0,1 g/hari. Keesokan hari setelah 7 hari perlakuan, mencit dikorbankan. Histopatologi gaster diamati dengan mikroskop lalu dinilai berdasarkan kriteria Wattimena. Analisis data menggunakan SPSS dengan uji Kruskal-Wallis lalu dilanjutkan uji Mann-Whitney. Dari hasil uji Kruskal-Wallis ada perbedaan bermakna antara keempat kelompok. Hasil uji Mann-Whitney menunjukkan perbedaan yang signifikan antara KP2 dengan KK, KP1, dan KP3. Tidak ada perbedaan signifikan antara KK dengan KP1 dan KP3, serta antara KP1 dengan KP3. Kopi robusta (Coffea canephora) green bean mempunyai pengaruh sebagai gastroprotektor terhadap gambaran histopatologi mukosa gaster mencit (Mus musculus) yang diinduksi aspirin. Kata Kunci : Kopi hijau, gastroprotektif, antioksidan. / Coffee has become a trend across the world, including Indonesia. Coffee has also been used as an alternative treatment for various disease. Coffee contain active compounds such as polyphenols and alkaloids, which are well-known as antioxidant. One of the most abundant coffee in Indonesia is Robusta coffee (Coffea canephora). Previous studies proved that robusta coffee accelerate the wound healing process. This study aim to know the gastroprotective activity of green robusta coffee bean (Coffea canephora) based on histopathology picture on aspirininduce gastric of mice (Mus musculus). This is a laboratory experimental study with posttest-only control design. In this study there are 4 groups, each group contain 6 mice. Negative control group (KN) was given normal feed and aquadest, first treatment group (KP1) was given coffee 0,1 g/day, second treatment group (KP2) was given aspirin 10 g/day, and third treatment group (KP3) was given aspirin 10 g/day then coffee 0,1 g/day. The next day after 7 days of treatment, the mice were sacrificed. Gastric histopathology were observed under microscope and assessed with Criteria of Wattimena. Data analysis using SPSS with Kruskal-Wallis test and continued by Mann-Whitney test. The result of Kruskal-Wallis test showed significant difference among four groups. The result of Mann-Whitney test showed significant difference between KKP2 with KK, KP1, and KP3. There is no significant difference between KK with KP1 an KP3, also between KP1 with KP3. Green robusta coffee bean (Coffea canephora) has effect as a gastroprotective to histopathology picture on aspirin-induce gastric of mice (Mus musculus). Keywords : Green bean, gastroprotective, antioxidan

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