Pengaruh Terapi Autologous Stromal Vascular Fraction Terhadap Penurunan Kadar HBA1C pada Pasien Diabetes Melitus Tipe 2 di Klinik Hayandra Tahun 2016

Novriandina, Shanaz (2016) Pengaruh Terapi Autologous Stromal Vascular Fraction Terhadap Penurunan Kadar HBA1C pada Pasien Diabetes Melitus Tipe 2 di Klinik Hayandra Tahun 2016. S1 thesis, Universitas Kristen Indonesia.

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Abstract

Terapi autologous Stromal Vascular Fraction (SVF) dalah salah satu terapi alternatif pada pengobatan Diabetes Melitus (DM) tipe 2 yang berpotensi dalam regenerasi sel β pankreas. Kadar HbA1c ≤7% ditetapkan sebagai indikator efikasi pengobatan diabetes melitus tipe 2. Penelitian ini bertujuan untuk menganalisis pengaruh terapi autologous SVF terhadap penurunan kadar HbA1c pada pasien DM tipe 2 di Klinik Hayandra tahun 2016. Desain penelitian ini adalah analitik observasional dengan menggunakan 30 data rekam medik pasien DM 2 yang mendapatkan terapi autologous SVF dan dianalisis dengan menggunakan uji paired t-test. Hasil penelitian menunjukkan terdapat 24 pasien mengalami penurunan kadar HbA1c, 4 pasien mengalami peningkatan kadar HbA1c, dan 2 pasien tidak mengalami perubahan kadar HbA1c setelah 1 bulan mendapatkan terapi autologous SVF. Berdasarkan indikator efektivitas pengobatan yang ditinjau dari kadar kadar HbA1c, didapatkan peningkatan persentase pasien DM tipe 2 dengan kadar HbA1c terkontrol dari 37% menjadi 47%, sedangkan persentase pasien DM tipe 2 dengan kadar HbA1c tidak terkontrol mengalami penurunan dari 63% menjadi 53%. Hasil analisis paired ttest diperoleh p-value = 0,003. Dengan demikian dapat disimpulkan adanya perbedaan yang signifikan antara terapi autologous SVF dan penurunan kadar HbA1c. Kata Kunci: Diabetes melitus Tipe 2; Kadar HbA1c; Stromal Vascular Fraction. / Autologous Stromal Vascular Fraction (SVF) is one of the alternative therapy for type 2 diabetes mellitus that might have potential to regenerate pancreatic beta cells. HbA1c levels ≤7% is an effication indicator for type 2 diabetes mellitus treatment. The aim of this research is to analyse the effect of autologous SVF therapy on decreasing HbA1c levels of type 2 diabetes patients at Hayandra Clinic in 2016. Design of this research is an observational analytic by obtaining 30 type 2 diabetes mellitus patient’s medical records after autologous SVF therapy and analyze by using paired t-test. The results showed decreasing of HbA1c levels in 24 patiens, increasing HbA1c levels in 4 patients, and 2 patiens had no changes of HbA1c levels after 1 month got autologous SVF therapy. Based on HbA1c levels as an effication indicator, there where increased percentage of type 2 diabetes mellitus patients with good HbA1c control from 37% into 47%, while the percentage of type 2 diabetes mellitus patients with poor HbA1c control were decreased from 63% into 53%. The analytic paired t-test result showed p-value = 0,003. In conclution, there was correlation between autologous SVF therapy and the decreasing of HbA1c levels in type 2 diabetes mellitus patients. Keywords: Type 2 diabetes mellitus; HbA1c levels; Stromal Vascular Fraction.

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