Profil Status Hormonal dan Faktor Pertumbuhan Tumor pada Pasien Kanker Payudara di RSUP Fatmawati Periode Februari-Desember Tahun 2017

Amiria, Prita Alif (2018) Profil Status Hormonal dan Faktor Pertumbuhan Tumor pada Pasien Kanker Payudara di RSUP Fatmawati Periode Februari-Desember Tahun 2017. S1 thesis, Universitas Kristen Indonesia.

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Abstract

Pemeriksaan imunohistokimia (IHK) merupakan salah satu metode pemeriksaan patologi anatomik menggunakan antibodi sebagai probe untuk mendeteksi antigen pada jaringan kanker payudara yang telah di biopsi. Hasil pemeriksaan IHK mencakup reseptor hormonal (ER dan PR), HER2, KI-67, dan TopoisomeraseIIalfa, yang bermanfaat untuk menentukan pengobatan dan prognosis. Penelitian ini bertujuan untuk mengetahui profil status hormonal dan faktor pertumbuhan tumor di RSUP Fatmawati periode Februari-Desember tahun 2017, berupa usia, hasil pemeriksaan IHK (ER, PR, HER-2, Ki-67, TopoisomeraseIIα), invasi limfo-vaskular, grading histopatologis, dan kelenjar getah bening (KGB) yang terlibat. Penelitian ini merupakan penelitian studi deskriptif retrospektif dengan menggunakan data rekam medik pasien kanker payudara di RSUP Fatmawati sebanyak 108 pasien sesuai dengan kriteria inklusi dan ekslusi. Hasil penelitian ini: kelompok usia frekuensi terbanyak 40-49 dan 50-59 tahun sebanyak 37,9%. Invasi limfovaskular positif dengan grade II sebanyak 45,3%. Metastasis ke KGB aksila sebanyak 35,1%. Reseptor hormonal positif didapatkan sebanyak 79,6%. HER-2 positif sebanyak 17,6%. Ki-67 proliferasi tinggi sebanyak 51,8%. Topoisomerase IIα positif sebanyak 54,6%. Pasien dengan subtipe Luminal B sebanyak 30,55%. Kata kunci: Kanker payudara, patologi anatomi, Imunohistokimia. / Immunohistochemistry (IHC) is a method of pathology anatomy examination using antibodies as a probe to detect antigen in breast cancer tissue that has been biopsied. Immunohistochemistry examination results include hormonal receptor (ER and PR), HER2, KI-67, and Topoisomerase IIα. These four antigens can be grouped into subtypes that are useful for determining treatment and prognosis. This study aims to determine the profile of hormonal status and tumor growth factor at Fatmawati General Hospital from February to December 2017, in the form of age, IHC examination result (ER, PR, HER-2, Ki-67, TopoisomeraseII α), lympho-vascular invasion, histopathological grade, and the metastases to lymph glands. This study is a retrospective descriptive study using medical record data of breast cancer patients in Fatmawati Hospital as many as 108 medical records in accordance with inclusion and exclusion criteria. This study obtained the results: age group with the highest frequency are 40-49 and 50-59 years, 37,9% each. Lympho-vascular invasion positive with grade II, was found in 45,3% patients. Metastases to axillary lymph glands was found in 35,1% patients. Receptor hormonal positive was found in 79,6% patients and HER-2 positive 17,6% patients. High proliferation Ki-67 was found in 51,8% patients. Topoisomerase IIα positive was found in 54,6% patients. Luminal B subtype was found in 30,55% patients. Keyword: Breast cancer, pathology anatomy, Immunohistochemistry.

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