Gambaran Kadar Ureum dan Kreatinin pada Pasien Dispepsia yang Mengonsumsi Obat Golongan Proton Pump Inhibitor di Rumah Sakit Universitas Kristen Indonesia Tahun 2018

Siborutorop, Richard Manzo (2020) Gambaran Kadar Ureum dan Kreatinin pada Pasien Dispepsia yang Mengonsumsi Obat Golongan Proton Pump Inhibitor di Rumah Sakit Universitas Kristen Indonesia Tahun 2018. S1 thesis, Universitas Kristen Indonesia.

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Abstract

Dispepsia merupakan masalah kesehatan yang sering ditemui oleh dokter dalam praktik sehari-hari. Banyak orang mengeluhkan gejala dispepsia tetapi tidak mencari pertolongan untuk pengobatan. Obat golongan proton pump inhibitor merupakan salah satu obat untuk penanganan dispepsia seperti omeprazol, lansoprazol, esomeprazol, rabeprazol, pantoprazol. Beberapa penelitian menjelaskan bahwa obat proton pump inhibitor dapat mengganggu fungsi ginjal dimana diakibatkan oleh terjadinya acute interstitial nephritis akibat konsumsi proton pump inhibitor dan kondisi ini dapat berakhir dengan chronic kidney disease yang terjadi karena tidak terdiagnosanya acute interstitial nephritis. Tujuan dilakukannya penelitian ini untuk melihat bagaimana kadar ureum dan kreatinin pada pasien dispepsia di Rumah Sakit Universitas Kristen Indonesia yang mengonsumsi obat proton pump inhibitor. Penelitian ini merupakan penelitian deskriptif content analysis, hospital-based. Berdasarkan hasil rekam medik di Rumah Sakit Universitas Kristen Indonesia pada tahun 2018, ditemukan kadar ureum tinggi sebesar 80,3% dan kadar ureum normal sebesar 19,7%. Pada kadar kreatinin, ditemukan bahwa pada pria ditemukan lebih banyak memiliki kadar kreatinin normal sebesar 57,7% dan kadar kreatinin tinggi sebesar 42,3% dan pada wanita ditemukan lebih banyak memiliki kadar kreatinin normal sebesar 62,5% dan kadar kreatinin tinggi sebesar 37,5% Kata Kunci: Dispepsia, Proton Pump Inhibitor, Kreatinin, Ureum. / Dyspepsia is a health problem often encountered by doctors in daily practice. Many people complain of symptoms of dyspepsia but do not seek help for treatment. Proton pump inhibitors are one of the drugs for the treatment of dyspepsia such as omeprazol, lansoprazol, esomeprazol, rabeprazol, pantoprazol. Some studies have explained that proton pump inhibitor drugs can interfere with kidney function due to acute interstitial nephritis due to the consumption of proton pump inhibitors and this condition can end with chronic kidney disease that occurs due to the undiagnosed acute interstitial nephritis. The purpose of this study was to see how ureum and creatinine levels in dyspepsia patients at Universitas Kristen Indonesia Hospital were taking proton pump inhibitors. This research is a descriptive research content analysis, hospital-based. Based on medikal records at Universitas Kristen Indonesia Hospital in 2018, 80.3% high ureum levels and 19.7% normal ureum levels were found. In creatinine levels, it was found that in men it was found to have more normal creatinine levels of 57.7% and high ureum levels of 42.3% and in women found to have more normal creatinine levels of 62.5% and high creatinine levels of 37.5%. Keywords : Dyspepsia, Proton Pump Inhibitor, Creatinine, Ureum.

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