Efficacy of topical povidone iodine ear drops 5% in chronic suppurative otitis media

Utomo, Bambang Suprayogi Resi and Kusumawati, Dyah Sari and Saputra, Egon Ilman and Hanny, Hervina Restianty (2023) Efficacy of topical povidone iodine ear drops 5% in chronic suppurative otitis media. ORLI, 53 (1). pp. 66-71. ISSN 2598-3970

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Abstract

Latar belakang: Povidone iodine (PVP-I) adalah antiseptik yang diketahui dapat membunuh atau menghambat pertumbuhan mikroorganism. Dalam beberapa penelitian PVP-I 5% dinyatakan sebanding atau lebih baik dari antibiotik topikal, namun sebagai obat tetes telinga, untuk tatalaksana otitis media supuratif kronik (OMSK) manfaatnya belum sepenuhnya jelas. Antibiotik topikal dalam bentuk tetes telinga sering digunakan dalam pengobatan OMSK. Adanya masalah perubahan pola kepekaan kuman terhadap antibiotik, serta harga yang cukup mahal, dirasa perlu dilakukan penelitian untuk membandingkan efektivitas tetes telinga PVP-I 5% dengan tetes telinga antibiotik. Tujuan: Mengetahui efektivitas PVP-I 5% dalam tatalaksana OMSK. Tinjauan pustaka: Dilakukan telaah sistematis dan meta analisis literatur mengenai penggunaan tetes telinga PVP-I 5% dibandingkan dengan antibiotik tetes telinga untuk tatalaksana OMSK memakai database PubMed, Springer Link, Cochrane dan Google Scholar. Data kemudian dianalisis. Hasil: Didapatkan 407 artikel penelitian, dan setelah penyaringan tersisa 24 literatur. Hasil akhir penyaringan diperoleh 2 literatur yang memenuhi kriteria inklusi. Kesimpulan: Pada kedua literatur tersebut, pemberian ttopikal PVP-I 5% memberi hasil pengobatan sama baiknya dengan penggunaan tetes telinga antibiotik, serta tidak ditemukan adanya efek samping pengobatan. Dibutuhkan penelitian lebih lanjut untuk mengetahui efektivitas pemberian PVP-I 5% topikal pada pengobatan OMSK. Kata kunci: otitis media supuratif kronis, povidone iodine, tetes telinga, efektivitas. / Background: Povidone iodine (PVP-I) is a well-known antiseptic and chemical compound to kill and inhibit the growth of microorganisms. PVP-I 5% antiseptics are expected to have similar or better clinical efficacy compared with topical antibioticsin Chronic Suppurative Otitis Media (CSOM) patients but this is not fully clear. Topical antibiotics in the form of ear drops are often used in CSOM therapy. As there was a raising concern of microbialsusceptibility towards antibiotics, and also the price of antibiotic ear drops are fairly expensive, it was essential to find the effectiveness of PVP-I 5% compared with antibiotic ear drops. Purpose: To find out the clinical efficacy of povidone iodine 5% in CSOM patients. Literature review: Conducted in accordance with the Cochrane Handbook for Systematic Review and Intervention, in adherence with the Preferred Reporting Itemsfor Systematic Reviews and Meta-Analyses. Several databases including Google Scholar, PubMed, Springer Link, and Cochrane were employed. The collected data were then analyzed. Result: A total of 407 research articles were included in this analysis obtaining 24 literatures. Final result, only 2 literatures met the inclusion criteria. Conclusion: Our analysis revealed that PVP-I 5% had similar efficacy with topical antibiotics, and there were no side effects of treatment. More evidence-based research is needed to determine the effectiveness of topical PVP-I 5% in the treatment of CSOM. Keywords: chronic suppurative otitis media, povidone iodine, ear drops, efficacy

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