Efek Pemberian Ekstrak Daun Sirsak Terhadap Kadar Icam-1 Serum Pada Hewan Model Kanker Kolorektal

Aditya, Ronald (2018) Efek Pemberian Ekstrak Daun Sirsak Terhadap Kadar Icam-1 Serum Pada Hewan Model Kanker Kolorektal. S1 thesis, Universitas Kristen Indonesia.

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Abstract

Secara tradisional, Annona muricata (sirsak) digunakan sebagai obat herbal. Masyarakat menggunakan daun sirsak sebagai minuman teh untuk mengobati beberapa penyakit, termasuk kanker. Saat ini, kanker kolorektal adalah keganasan paling umum ketiga di Asia yang dialami oleh pria dan wanita.1 Salah satu pemeriksaan kanker atau diagnostik dengan serum intercellular adhesion molecule-1 (ICAM-1) yang meningkat pada pasien kanker kolorektal. Tujuan penelitian ini adalah untuk mengetahui pengaruh ekstrak daun sirsak (Anonna muricata) terhadap berat data dan konsentrasi pemeriksaan serum ICAM-1 pada kelompok model karsinogenesis. Data penelitian ini dianalisis menggunakan independent t-test method. Selama 8 minggu studi pada kedua kelompok, tidak ada hasil yang signifikan. Berdasarkan hasil penelitian yang telah dilakukan, perlakuan kontrol negatif dan ESFAM 50mg/kgBB pada berat badan mencit memiliki signifikansi 0,231 (p> 0,05 ) di mana nilainya tidak signifikan atau tidak signifikan. selain itu, perlakuan kontrol negatif dan ESFAM 50mg/kgBB terhadap ICAM memiliki nilai signifikan 0,89 (p> 0,05) dimana nilainya menunjukkan tidak signifikan. Kata kunci: Annona muricata, obat herbal, karsinogenensis, intercellular adhesion molecules-1, antikanker, Independent T-test Traditionally, Annona muricata (soursop) is used as an herbal medicine. People use soursop leaves as tea drinks to treat several diseases, including cancer. At present, colorectal cancer is the third most common malignancy in men and women.1 One cancer or diagnostic examination with intercellular adhesion molecules-1 (ICAM-1) serum is increased in colorectal cancer patients. The purpose of this study was to determine the effect of soursop leaf extract (Anonna muricata) on the weight of the data and the concentration of serum ICAM-1 examination in the carcinogenesis model groups. The data of this study were analyzed using the independent t-test method. During the 8 weeks of study in both groups, there were no significant results. Based on the results of the research that has been done, the negative control treatment and 50mg/kgBB ESFAM on the body weight of mice have a significance of 0.231 (p> 0.05) where the value is not significant or not significant. Besides, the negative control treatment and ESFAM 50mg/kgBB against ICAM has a significant value of 0.89 (p> 0.05) where the value indicates not significant. Key words: Annona muricata leaf, herbal medicine, karsinogenensis, intercellular adhesion molecules-1, antikanker, Independent T-test

Item Type: Thesis (S1)
Subjects: SCIENCE > Physiology > Experimental pharmacology
MEDICINE
MEDICINE > Internal medicine
MEDICINE > Internal medicine > Neoplasms. Tumors. Oncology Including cancer and carcinogens
MEDICINE > Therapeutics. Pharmacology
Divisions: FAKULTAS KEDOKTERAN > Pendidikan Dokter
Depositing User: Mr Alexander Jeremia
Date Deposited: 10 Feb 2020 07:32
Last Modified: 10 Feb 2020 07:32
URI: http://repository.uki.ac.id/id/eprint/1182

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